survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.
| Target |
BIRC5 |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC, IF/ICC, FCM |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human BIRC5 expressed in E. Coli. |
| Purification |
Purified antibody |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
16 kDa |
| Swiss Prot |
O15392
|
| GeneID |
332
|
| Gene Symbol |
BIRC5 |
| OMIM |
603352
|
| HGNC |
593 |
| Ensembl |
ENSG00000089685 |
| Concentration |
1.0 mg/ml |
| Buffer |
PBS with 0.05% sodium azide and 0.5% protein stabilizer. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |