SREBF1 Antibody is a Rabbit Polyclonal antibody against SREBF1. This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Target	SREBF1
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IHC, FCM
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/100, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant protein of human SREBF1.
Purification	Affinity purified.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at 2°C to 8°C upon receipt.
Molecular Weight	Calculated MW: 45 kDa/48 kDa/111 kDa/113 kDa/121 kDa/124 kDa Observed MW: 122 kDa
Swiss Prot	P36956
GeneID	6720
Gene Symbol	SREBF1
Concentration	> 1 mg/ml
Buffer	PBS, pH 7.3, 0.02% sodium azide.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.