SYK Antibody is a Rabbit Polyclonal antibody against SYK. Syk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cellsSyk interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptorsIt couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including prolifeRation, differentiation, and phagocytosisThere is also evidence of a role for Syk in nonimmune cells, and investigators have indicated that Syk is a potential tumor suppressor in human breast carcinomasTyr323 is a negative regulatory phosphorylation site within the SH2-kinase linker region in SykPhosphorylation of Tyr323 provides a direct binding site to the TKB domain of CblTyrosine 352 of Syk is involved in the association of PLC-γ1Tyrosines 525 and 526 are located in the activation loop of the Syk kinase domain, and phosphorylation of Tyr525/526 of human Syk (equivalent to the Tyr519/520 of mouse Syk) is essential for Syk function.
| Target |
SYK |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human SYK. |
| Purification |
Affinity Chromatography. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P43405
|
| GeneID |
6850
|
| Gene Symbol |
SYK |
| Buffer |
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |