SUMO1 Antibody is a Rabbit Polyclonal antibody against SUMO1. Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein familyThe covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitinationThis post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature proteinMature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target proteinUbiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functionsUbiquitin predominantly regulates degradation of its targetIn contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stabilitySUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease.

Target	SUMO1
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM, IP
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, ICC: 1/50 - 1/200, IP: 1/20 - 1/50, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthetic peptide of human SUMO-1.
Purification	Affinity Chromatography.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P63165
GeneID	7341
Gene Symbol	SUMO1
Buffer	PBS, pH7.3, containing 0.02% sodium azide and 50% Glycerol.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.