RRM2 Antibody is a Rabbit Polyclonal antibody against RRM2. Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5'-diphosphates into 2'-deoxyribonucleotides, a rate-limiting step in the production of 2'-deoxyribonucleoside 5'-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair [PMID:20825972, 19250552]. RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit.
| Target |
RRM2 |
| Reactivity |
Human, Mouse |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB, IF/ICC, IP |
| Recommended dilutions |
WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100, IP: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human RRM2. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 44 kDa/51 kDa
Observed MW: 45 kDa |
| Swiss Prot |
P31350
|
| GeneID |
6241
|
| Gene Symbol |
RRM2 |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |