REG1A (regenerating islet-derived 1 alpha), also known as PTP, PSP, is a member of the Reg family of secreted proteins with a C-type lectin domain. REG1A is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis.Due to variable glycosylation, pancreatic REG1A exists as multiple species of 16 - 18 kDa. REG1A promotes the maintenance and growth of pancreatic islet beta cells and intestinal villi. It is upregulated in pancreatitis and some carcinomas. REG1A is an antigenic target in autoimmune diabetes.
| Target |
REG1A |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, IHC, IF/ICC |
| Recommended dilutions |
ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human REG1A fused with hIgGFc tag expressed in HEK293 cell line. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
19 kDa |
| Swiss Prot |
P05451
|
| GeneID |
5967
|
| Gene Symbol |
REG1A |
| OMIM |
167770
|
| HGNC |
9951 |
| Ensembl |
ENSG00000115386 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |