Wortmannin is a small molecule. Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.
| Target |
Wortmannin |
| Origin |
Synthetic |
| Purity |
≥98% |
| Form |
White to off-white solid. |
| CAS Number |
19545-26-7 |
| Storage |
Store at -20 °C. |
| Molecular Weight |
428.44 |
| Molecular Formula |
C23H24O8 |
| SMILES |
[C@@]15(C4=C(C(C2=C1[C@@H](C[C@]3([C@H]2CCC3=O)C)OC(=O)C)=O)OC=C4C(O[C@@H]5COC)=O)C |
| UNSPSC Code |
41116105 |
| Availability |
Shipped within 5-12 working days. |
| Note |
This product is for research use only. |