ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors.It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment.Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively.ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes.It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
| Target |
ZBTB7B |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC, IF/ICC |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human ZBTB7B expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
lgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
58 kDa |
| Swiss Prot |
O15156
|
| GeneID |
51043
|
| Gene Symbol |
ZBTB7B |
| OMIM |
607646
|
| HGNC |
18668 |
| Ensembl |
ENSG00000160685 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |