XBP1 Antibody is a Rabbit Polyclonal antibody against XBP1. This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X boxThis gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoterIt may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivatorIt has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1)The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factorThe isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stressA pseudogene of XBP1 has been identified and localized to chromosome 5.

Target	XBP1
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	ELISA, WB, IHC
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthetic peptide of human XBP1.
Purification	Affinity Chromatography.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P17861
GeneID	7494
Gene Symbol	XBP1
Buffer	PBS, pH7.3, containing 0.02% sodium azide and 50% Glycerol.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.