VDR Antibody is a Rabbit Polyclonal antibody against VDR. The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factorsUpon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene productsIt is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effectsDownstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancerDefects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A)A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperpaRathyroidismMost patients have total alopecia in addition to ricketsThis antibody is a rabbit polyclonal antibody to human VDR.
| Target |
VDR |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Purification |
Affinity Chromatography. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P11473
|
| GeneID |
7421
|
| Gene Symbol |
VDR |
| Buffer |
PBS, pH7.3, containing 0.02% sodium azide and 50% Glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |