AXL: AXL receptor tyrosine kinase, also known as UFO, JTK11.Entrez Protein NP_001690.It is a member of the receptor tyrosine kinase subfamily.Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats.It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6.It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding.Alternatively spliced transcript variants encoding different isoforms have been identified.
| Target |
Tyrosine-Protein Kinase Receptor UFO (AXL) |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IF/ICC |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
97.4 kDa |
| Swiss Prot |
P30530
|
| GeneID |
558
|
| Gene Symbol |
AXL |
| OMIM |
109135
|
| HGNC |
905 |
| Ensembl |
ENSG00000167601 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |