Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development.Activation of B cells by various ligands is accompanied by activation of Blk.It has been suggested that Blk is involved in the control of B cell differentiation and proliferation.Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis.Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response.
| Target |
BLK |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IF/ICC, FCM |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human BLK expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
58 kDa |
| Swiss Prot |
P51451
|
| GeneID |
640
|
| Gene Symbol |
BLK |
| OMIM |
191305
|
| HGNC |
1057 |
| Ensembl |
ENSG00000136573 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |