CD40 is a member of the tumour necrosis factor (TNF) receptor super family, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.

Target	CD40
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 µl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant protein (Human CD40).
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG2b
Conjugation	CF-Blue
Specificity	CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions.
Storage	Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.
Molecular Weight	48 to 50 kDa
Swiss Prot	P25942
GeneID	958
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
UNSPSC Code	12352203
Availability	Shipped within 2-3 weeks.
Note	This product is for research use only.