The protein encoded by this gene is a member of the TNF-receptor superfamily.This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption.This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development.Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification.Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
| Target |
TNFRSF11B |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human TNFRSF11B expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
60 kDa |
| Swiss Prot |
O00300
|
| GeneID |
4982
|
| Gene Symbol |
TNFRSF11B |
| OMIM |
602643
|
| HGNC |
11909 |
| Ensembl |
ENSG00000164761 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |