TPM1 Antibody is a Rabbit Polyclonal antibody against TPM1. Tropomyosin-1 (TPM1) belongs to the high molecular weight members of tropomyosin familyThe protein exists in an alpha-helical coiled-coil conformation and binds multiple acting monomers in a tight manner to stabilize and regulate the actin filamentTropomyosins fullfill functions in muscle and non-muscle cellsIn muscle cells, tropomyosins associate with the troponin complex and play a central role in the calcium-dependent regulation of striated muscle contraction in vertebRatesIn non-muscle cells, tropomyosins are implicated in the formation and stabilization of cytoskeletal actin filaments to ensure normal cellular processesMutations of tropomysin-1 have been reported as a cause of dilated cardiac myopathiesTropomyosin-1 also functions as a tumor suppressor, and many malignant tumors demonstRate downregulation of tropomyosin-1 expressionTropomyosin-1 is phosphorylated at Ser283 through the Erk/DAPK pathway, which promotes stress fiber formation in response to oxidative stress.

Target	TPM1
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	ELISA, WB, IHC
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant protein of human TPM1.
Purification	Affinity Chromatography.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P09493
GeneID	7168
Gene Symbol	TPM1
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.