TLR4 Antibody is a Rabbit Polyclonal antibody against TLR4. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	TLR4
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, FCM
Recommended dilutions	WB: 1/500 - 1/1000, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthetic peptide of human TLR4.
Purification	Affinity purified.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at 2°C to 8°C upon receipt.
Molecular Weight	Calculated MW: 73 kDa/91 kDa/95 kDa Observed MW: 97 kDa
Swiss Prot	O00206
GeneID	7099
Gene Symbol	TLR4
Concentration	> 1 mg/ml
Buffer	PBS, pH 7.3, 0.02% sodium azide.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.