THRB Antibody is a Rabbit Polyclonal antibody against THRB. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronineIt is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormoneKnockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormoneMutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH)Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
| Target |
THRB |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human THRB. |
| Purification |
Affinity Chromatography. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P10828
|
| GeneID |
7068
|
| Gene Symbol |
THRB |
| Buffer |
PBS, pH7.3, containing 0.02% sodium azide and 50% Glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |