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| Product Name | Recombinant Human Caspase-1 |
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| Description | 120-269aa; Partial. MW: 44.2kD. Purity >90% as determined by SDS-PAGE. Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. |
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| Size | 0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Interleukin-1 beta convertase; IL-1B; CInterleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45] |
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| Gene, Accession, CAS # | CASP1, Gene ID: 834, Accession: NP_001214.1 |
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| Catalog # | MBS717132 |
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| Order / More Info | Recombinant Human Caspase-1 from MYBIOSOURCE INC. |
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| Product Specific References | A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.Thornberry N.A., Bull H.G., Calaycay J.R., Chapman K.T., Howard A.D., Kostura M.J., Miller D.K., Molineaux S.M., Weidner J.R., Aunins J., Elliston K.O., Ayala J.M., Casano F.J., Chin J., Ding G.J.-F., Egger L.A., Gaffney E.P., Limjuco G., Palyha O.C., Raju M., Rolando A.M., Salley J.P., Yamin T.-T., Lee T.D., Shively J.E., McCross M., Mumford R.A., Schmidt J.A., Tocci M.J.Nature 356:768-774(1992) M |
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