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| Product Name | RSPO-2, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE). Roof plate-specific Spondin 2 isoform 1 (R-Spondin 2, RSPO2), also known as cysteine-rich and single thrombospondin domain containing protein 2 (Cristin 2), is a 33kD secreted protein that belongs to the R-Spondin family. The four R-Spondins regulate Wnt/B-catenin signaling and overlap in expression and function. Like other R-Spondins, RSPO2 contains two adjacent cysteine-rich furin-like domains aa90-134 followed by a thrombospondin (TSP-1) motif aa144-204 and a C-terminal region rich in basic residues aa207-243. The basic region binds heparin and mediates cell surface retention and extracellular matrix attachment while the furin-like domains are required for Wnt/B-catenin signaling. RSPO2 contains one potential N-glycosylation site. Mature mouse RSPO2 shares 97-98% aa identity with human, rat, equine, canine and bovine RSPO2 and ~40% aa identity with RSPO1, RSPO3 and RSPO4. One potential 237aa mouse isoform diverges after aa206 and lacks a basic region. Human R |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RSPO-2, Recombinant, Mouse (Rspo2, R-spondin-2, Cysteine-rich and Single Thrombospondin Domain-containing Protein 2, Cristin-2, mCristin-2, Roof Plate-specific Spondin-2) |
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| Gene, Accession, CAS # | Accession: NP_766403 |
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| Catalog # | R9417-48 |
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| Order / More Info | RSPO-2, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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