| 产品详情 |
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| Product Name | Fexaramine |
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| Description | Purity >98%. The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (; EC50 = 80 nM). Fexaramine does not display activity at the following nuclear receptors: hRXRAlpha, hPPARAlphaGammaDelta, mPXR, hPXR, hLXRAlpha, hTRBeta, hRARBeta, mCAR, mERRGamma, or hVDR. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid, methyl ester |
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| Gene, Accession, CAS # | CAS: 574013-66-4 |
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| Catalog # | LS-H7779 |
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| Price | |
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| Order / More Info | Fexaramine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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