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| Antigenic Specificity | CD274 (PD-L1, B7-H1) |
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| Clone | MIH1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH1), eBioscience™. Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. |
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| Immunogen | n/a |
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| Other Names | B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1 |
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| Gene, Accession # | Entrez: 29126; Uniprot: Q9NZQ7 |
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| Catalog # | 14-5983-82 |
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| Price | |
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| Order / More Info | CD274 (PD-L1, B7-H1) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15837746, 16282703, 16611412, 18585785, 18775867, 18830259, 19155478, 19380770, 19451266, 19794071, 20007827, 20460501, 20617899, 20886079, 21224361, 21349174, 21555531, 21816363, 21856939, 21876620, 22389764, 23028594, 23284620, 23460533, 23585913, 23661793, 23818845, 23918985, 24154626, 25154680, 25801435, 25902191, 26175924, 26228159, 26260996, 26321145, 26657115, 26834749, 26847035, 27076677, 27314219, 27671847, 27998726, 28233730, 28325288, 28903377, 29246442, 29409495, 29593314 |
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