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| Product Name | PD-1/PD-L1 Inhibitor 1 |
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| Description | Purity >98%. PD-1/PD-L1 inhibitor 1 is a compound that blocks the interaction of programmed cell death protein 1 (PD-1, CD279) with its ligand protein (PD-L1, CD274). In preliminary studies, PD-1/PD-L1 inhibitor 1 blocks this interaction with an IC50 value between 6 and 100 nM, as assessed by a homogenous time-resolved fluorescence binding assay. Antibodies that block PD-1/PD-L1 interaction reduce signaling between these co-inhibitory molecules and have shown promise as checkpoint immunomodulators in cancer clinical trials. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2S)-1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid, Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1 |
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| Gene, Accession, CAS # | CAS: 1675201-83-8 |
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| Catalog # | LS-H9303 |
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| Order / More Info | PD-1/PD-L1 Inhibitor 1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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