产品名称 Allograft Inflammatory Factor 1 (AIF1) (aa 99-114), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1673203
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityAllograft Inflammatory Factor 1 (AIF1) (aa 99-114), (C-Term)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatimmunogen affinity purified
Size100 µg
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionAIF1(Allograft inflammatory factor 1), also known as IRT-1, is a protein that in humans is encoded by the AIF1 gene. This gene is induced by cytokines and interferon. Its protein product is though to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. The gene expresses three transcripts. Using in vitro binding and coimmunoprecipitation assays, Autieri et al.(2003) determined that AIF1 interacts with actin. In unstimulated VSMCs, AIF1 colocalized with F-actin, but translocated to lamellipodia upon PDGF stimulation. VSMCs stably transduced with AIF1 retrovirus migrated 2.6-fold more rapidly in response to PDGF than control cells. AIF1 colocalized with RAC1, and AIF1-transduced VSMCs showed a constitutive and enhanced activation of RAC1. Autieri et al.(2003) concluded that AIF1 binds and polymerizes F-actin and regulates RAC1 activity and VSMC migration.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human Iba1(99-114aa ETFSYPDFLRMMLGKR), different from the related rat and mouse sequences by one amino acid.
Other Namesfa04b11|wu:fa04b11|AIF1|aif1|AIF-1|IBA1|IRT-1|IRT1|Bart1|iba1|mrf-1|AI607846|D17H6S50E|G1|Iba1|AIF|AIF1L
Gene, Accession #Gene ID: 199
Catalog #ABIN1673203
Price
Order / More InfoAllograft Inflammatory Factor 1 (AIF1) (aa 99-114), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 9614071, 12714565
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