| 产品详情 |
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| Product Name | AK-7 |
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| Description | Purity >95%. The sirtuin SIRT2 is a deacetylase which targets Alpha-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer's, Huntington's, and Parkinson's diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 µM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide |
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| Gene, Accession, CAS # | CAS: 420831-40-9 |
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| Catalog # | LS-H6458 |
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| Price | |
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| Order / More Info | AK-7 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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