| 产品详情 |
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| Product Name | Buthionine Sulfoximine |
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| Description | Purity >98%. L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of Gamma-glutamylcysteine synthetase (Ki <100 µM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of L-buthionine-(S,R)-sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, L-buthionine-(S,R)-sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid, NSC 326231 |
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| Gene, Accession, CAS # | CAS: 83730-53-4 |
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| Catalog # | LS-H6923 |
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| Order / More Info | Buthionine Sulfoximine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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