| 产品详情 |
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| Antigenic Specificity | PDCD1 / CD279 / PD-1 |
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| Clone | MIH4 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | affinity purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | Flo (1:10 - 1:200), IHC, IHC-Fr |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PDCD1 / CD279 / PD-1 Antibody (clone MIH4) LS-C58040. Detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. |
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| Immunogen | Human CD279 - transfected L cells. |
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| Other Names | PDCD1, CD279, HPD-1, HPD-l, PD1, Protein PD-1, SLEB2, PD-1, CD279 antigen, Programmed cell death 1 |
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| Gene, Accession # | PDCD1, Gene ID: 5133 |
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| Catalog # | LS-C58040 |
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| Price | |
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| Order / More Info | PDCD1 / CD279 / PD-1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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