| 产品详情 |
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| Antigenic Specificity | CTLA4 / CD152 |
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| Clone | 1B8 |
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| Host Species | Hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | Protein G purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, Flo (1:10 - 1:100), IF, IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CTLA4 / CD152 Antibody (clone 1B8) LS-C188474. Recognizes mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naive T-cells and is induced upon T-cell activation. In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis. Clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumor immunity. |
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| Immunogen | Extracellular portion of mouse CD152 fused to a mouse IgG2a. |
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| Other Names | CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform |
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| Gene, Accession # | CTLA4, Gene ID: 1493 |
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| Catalog # | LS-C188474 |
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| Price | |
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| Order / More Info | CTLA4 / CD152 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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