| 产品详情 |
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| Product Name | NS 6180 |
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| Description | Purity >98%. NS 6180 is an inhibitor of the intermediate-conductance calcium-activated potassium channel 3.1 (IKCa1/KCa 3.1; IC50 = 9.4 nM in HEK293 cells expressing the human channel). It inhibits hyperpolarization of human, mouse, and rat erythrocytes induced by the calcium ionophore A23187 (IC50 s = 14, 15, and 9 nM, respectively). NS 6180 is selective for IKCa1/KCa 3.1 over voltage-gated sodium (Nav ) and most voltage-gated potassium channels (Kv ) but does inhibit KCa 1.1, Kv 1.3, and Kv 11.1 channels by greater than 50% at 10 µM. It is selective for potassium channels over G protein-coupled receptors and ion channels, inhibiting only the norepinephrine and dopamine transporters, L-type calcium channel, and melatonin receptor MT1 by greater than 50% in a panel of 69 receptors and channels. NS 6180 inhibits T-lymphocyte activation and the release of the Th1 cytokines IL-2 and IFN-Gamma in vitro (IC50 = ~50 nM). It also increases proliferation of natural killer (NK) cells and selectively increases cytotoxicity of adherent, but not non-adherent, NK cells. In a rat model of inflammatory bowel disease (IBD) induced by DNBS, NS 6180 (3 and 10 mg/kg per day) decreases colon inflammation and improves weight gain. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[[3-(trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one |
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| Gene, Accession, CAS # | CAS: 353262-04-1 |
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| Catalog # | LS-H9077 |
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| Order / More Info | NS 6180 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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