| 产品详情 |
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| Product Name | NS309 |
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| Description | Purity >98%. NS309 is a nonselective activator of small- and intermediate-conductance Ca2+ -activated K+ (SK/KCa 2 and IK/KCa 3.1) channels (EC50 s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv 11.1 channels (hERG; IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa 1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6,7-dichloro-1H-indole-2,3-dione 3-oxime |
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| Gene, Accession, CAS # | CAS: 18711-16-5 |
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| Catalog # | LS-H9079 |
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| Price | |
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| Order / More Info | NS309 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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