| 产品详情 |
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| Product Name | NS3694 |
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| Description | Purity >98%. Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c -induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 µM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-Alpha or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzoic acid, Apoptosis Inhibitor II |
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| Gene, Accession, CAS # | CAS: 426834-38-0 |
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| Catalog # | LS-H9080 |
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| Price | |
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| Order / More Info | NS3694 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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