| 产品详情 |
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| Antigenic Specificity | SOX10, aa115-269 |
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| Clone | rSOX10/1074 |
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| Host Species | Recombinant Mouse |
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| Reactive Species | human |
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| Isotype | IgG1,k |
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| Format | Protein A/G purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC-Fx, SDS-PAGE |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SOX10 Antibody (aa115-269, clone rSOX10/1074) LS-C751360. Specificity: SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells. |
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| Immunogen | Recombinant human SOX10 protein fragment (around aa115-269). Antigen Molecular Weight: 49-58 kDa |
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| Other Names | SOX10, DOM, Transcription factor SOX-10, WS4, PCWH, WS2E, SRY-related HMG-box gene 10, WS4C |
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| Gene, Accession # | SOX10, Gene ID: 6663 |
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| Catalog # | LS-C751360 |
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| Price | |
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| Order / More Info | SOX10, aa115-269 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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