| 产品详情 |
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| Product Name | CK-636 |
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| Description | Purity >98%. Actin-related protein 3 (Arp3) heterodimerizes with Arp2 to form the Arp2/3 complex, which is involved in actin polymerization in a range of cell types. CK-636 is an inhibitor of Arp2/3 complex action that binds the complex and inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC50 s = 4, 32, and 24 µM, respectively). It is cell permeable, as it prevents actin polymerization and the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50 = 22 µM). CK-636 is used to explore the role of Arp2/3 complex in cellular functions, including epidermal barrier formation and T cell migration. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(2-methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide |
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| Gene, Accession, CAS # | CAS: 442632-72-6 |
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| Catalog # | LS-H7177 |
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| Order / More Info | CK-636 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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