| 产品详情 |
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| Antigenic Specificity | TIMP1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rabbit, sheep, bovine, rat, horse, ferret, human |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA (2.5 - 10 µg/ml), IHC, IHC-P (1 - 5 µg/ml), WB (5 - 10 µg/ml) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TIMP1 Antibody LS-C11473. Recognizes human Tissue inhibitor of metalloproteinases 1, also known as TIMP-1, Metalloproteinase inhibitor 1, Erythroid-potentiating activity or Fibroblast collagenase inhibitor. TIMP-1 is a 207 amino acid, ~23 kD secreted glycoprotein containing a 23 amino acid signaling peptide and a single domain. TIMP-1 is a metalloproteinase inhibitor that functions by formation of complexes with target metalloproteinases, binding to their catalytic cofactor leading to irreversible inactivation of the target metalloproteinase. TIMP-1 also functions as a growth factor and activates signalling cascades via CD63 and CD29. In humans TIMP-1 also functions to promote growth and differentiation of erythroid progenitors. Recognizes both native and denatured TIMP-1, as well as TIMP-1 in and out of enzyme/inhibitor complex. Is not known to be neutralizing. TIMP-1 is expressed by a wide range of cells including microvascular endothelial cells, smooth muscle cells, mesangial cells and some fibroblasts. Has been used successfully for the localization of TIMP-1 in a rabbit model of hypertrophic scarring by immunohistochemistry on formalin fixed, paraffin embedded sections. |
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| Immunogen | Human tissue inhibitor of metalloproteinase 1 (TIMP-1). |
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| Other Names | TIMP1, CLGI, EPA, HCI, Metalloproteinase inhibitor 1, TIMP-1 |
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| Gene, Accession # | TIMP1, Gene ID: 7076 |
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| Catalog # | LS-C11473 |
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| Price | |
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| Order / More Info | TIMP1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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