| 产品详情 |
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| Antigenic Specificity | CD8a Molecule (CD8A) |
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| Clone | 53-6-7 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
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| Immunogen | Mouse spleen cells |
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| Other Names | cd8|LOC100136450|BB154331|Ly-2|Ly-35|Ly-B|Lyt-2|zgc:136643|CD8|Leu2|MAL|p32|RHACD8-4 |
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| Gene, Accession # | Gene ID: 12525 |
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| Catalog # | ABIN457303 |
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| Price | |
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| Order / More Info | CD8a Molecule (CD8A) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16549792, 11805130, 16785526, 398327, 6156984, 18263815, 1608966 |
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