| 产品详情 |
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| Product Name | cH2R-GsalphaS recombinant protein |
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| Description | cH2R GsalphaS is a fusion protein in which the GsalphaS N terminus is linked to the C terminus of the canine H2 receptor (cH2R) via a hexahistidine (His6)-tag. The H2R couples to Gs proteins to activate adenylate cyclase (AC). Among the many responses mediated by the H2R are gastric acid secretion, smooth muscle relaxation, ionotropic and chronotropic effects on heart muscle, and inhibition of leukocyte function. GsalphaS is the short splice variant of the subunit of the heterotrimeric G protein Gs. Gs activates the effector AC. The fusion protein cH2R GsalphaS ensures a defined 1:1 stoichiometry of the receptor and GsalphaS subunit. The fusion protein allows for highly sensitive analysis of receptor/G-protein coupling in terms of ternary complex formation, guanine nucleotide exchange and AC activity. The fusion protein contains a N terminal FLAG-tag for immunological detection. MW: 80 kDa |
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| Size | 1 ml |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Histamine H2-receptor-GsalphaS fusion protein |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | orb154351 |
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| Order / More Info | cH2R-GsalphaS recombinant protein from BIORBYT LTD. |
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| Product Specific References | n/a |
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