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| Product Name | BAY 11-7085 |
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| Description | Purity >98%. In the classical pathway of NF-?B activation, phosphorylation of the inhibitor of NF-?B (I?BAlpha) releases the inhibitor from NF-?B, allowing I?BAlpha degradation and NF-?B activation and nuclear import. BAY 11-7085 is an irreversible inhibitor of I?BAlpha phosphorylation, preventing activation of NF-?B by cytokines and lipopolysaccharide (IC50 = 10 µM). It blocks gene expression that is regulated through the classical pathway of NF-?B activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY 11-7085 is also used to study I?BAlpha actions that are independent of NF-?B signaling. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile |
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| Gene, Accession, CAS # | CAS: 196309-76-9 |
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| Catalog # | LS-H6744 |
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| Order / More Info | BAY 11-7085 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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