| 产品详情 |
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| Product Name | BAY 11-7082 |
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| Description | Purity >98%. The transcription factor NF-?B plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. In the cytoplasm, inactive NF-?B complexes are bound to an inhibitor I?B. However in response to certain stimuli, I?B is phosphorylated, ubiquitinated, and degraded, enabling the translocation of NF-?B to the nucleus. BAY 11-7082 selectively and irreversibly inhibits NF-?B activation by blocking TNF-Alpha-induced phosphorylation of I?B-Alpha without affecting constitutive I?B-Alpha phosphorylation. This compound inhibits the TNF-Alpha-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile |
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| Gene, Accession, CAS # | CAS: 19542-67-7 |
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| Catalog # | LS-H6743 |
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| Order / More Info | BAY 11-7082 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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