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| Product Name | MIRA-1 |
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| Description | Purity >99%. MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro ). Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione, NSC 19630 |
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| Gene, Accession, CAS # | CAS: 72835-26-8 |
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| Catalog # | LS-H8693 |
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| Order / More Info | MIRA-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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