| 产品详情 |
| Edit |   |
|---|
| Product Name | 2-(14,15-Epoxyeicosatrienoyl) Glycerol |
|---|
| Description | Purity >94%. 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. 2-AG is hydrolyzed by the enzyme monoacylglycerol lipase, terminating its biological activity, and metabolism by cyclooxygenase-2 and lipoxygenases has been documented. The related endocannabinoid, 2-arachidonoyl ethanolamide (AEA), can be metabolized by cytochrome P450 (CYP450) enzymes in human liver and kidney to a number of epoxy-ethanolamide derivatives. 2-(14,15-Epoxyeicosatrienoyl) Glycerol (2-14,15-EG) is a novel CYP450 metabolite of 2-AG in the kidney. 2-14,15-EG is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 µM. In these cells, 2-14,15-EG activates the metalloprotease ADAM17, which cleaves proTGF- alpha and releases TGF- alpha as a ligand that initiates the EGFR-ERK signalling pathway. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | (5Z,8Z,11Z)-13-(3-pentyl-2-oxiranyl)-5,8,11-tridecatrienoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, 2-14,15-EG |
|---|
| Gene, Accession, CAS # | CAS: 848667-56-1 |
|---|
| Catalog # | LS-H34 |
|---|
| Price | |
|---|
| Order / More Info | 2-(14,15-Epoxyeicosatrienoyl) Glycerol from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|