| 产品详情 |
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| Product Name | TAS 120 |
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| Description | Purity >98%. TAS 120 is an orally bioavailable inhibitor of fibroblast growth factor receptors (FGFRs) that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations. It prevents phosphorylation of FGFRs and impedes downstream signaling pathways in cells. TAS 120 blocks the proliferation of human cancer cell lines with FGFR gene abnormalities but does not alter the growth of cell lines with wild-type FGFR. It inhibits FGFR phosphorylation in tumors and tumor growth in human xenograft mouse models in a dose-dependent manner. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one |
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| Gene, Accession, CAS # | CAS: 1448169-71-8 |
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| Catalog # | LS-H10106 |
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| Order / More Info | TAS 120 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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