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| Antigenic Specificity | LRWD1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:1000, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LRWD1 Polyclonal Antibody. Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. |
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| Immunogen | n/a |
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| Other Names | CENP-33; ORCA; ORC-associated protein; centromere protein 33; leucine-rich repeat and WD repeat-containing protein 1; origin recognition complex associated; origin recognition complex-associated protein |
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| Gene, Accession # | Entrez: 71735; Uniprot: Q8BUI3 |
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| Catalog # | PA5-71585 |
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| Price | |
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| Order / More Info | LRWD1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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