| 产品详情 |
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| Antigenic Specificity | LSD1 |
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| Clone | 1B2E5 |
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| Host Species | Mouse |
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| Reactive Species | bovine, canine, human, mouse, nonhuman primate, rat |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 5-10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LSD1 Monoclonal Antibody (1B2E5). LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the |
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| Immunogen | n/a |
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| Other Names | RP1-184J9.1, AOF2, BHC110, KDM1, LSD1, BRAF35-HDAC complex protein BHC110, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, amine oxidase (flavin containing) domain 2, flavin-containing amine oxidase domain-containing protein 2, lysine (K)-specific demethylase 1, lysine-specific histone demethylase 1, lysine-specific histone demethylase 1A |
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| Gene, Accession # | Entrez: 23028, 478193, 500569, 532997, 99982; Uniprot: O60341, Q6ZQ88 |
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| Catalog # | 41-3300 |
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| Price | |
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| Order / More Info | LSD1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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