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| Antigenic Specificity | Phospho-Histone H2A.X (Ser139) |
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| Clone | HisH2AXS139-1E4 |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 200 µl |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.1-1.0 µg/mL, Western Blot: 0.1-1.0 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-Histone H2A.X (Ser139) Monoclonal Antibody (HisH2AXS139-1E4). Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle. In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX. The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs. The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner. Structurally, H2A.x contain |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 15270, 3014; Uniprot: P16104, P27661 |
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| Catalog # | MA5-28006 |
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| Price | |
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| Order / More Info | Phospho-Histone H2A.X (Ser139) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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