| 产品详情 |
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| Antigenic Specificity | KSR2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | KSR2 Polyclonal Antibody. Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. |
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| Immunogen | n/a |
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| Other Names | KSR2; Kinase suppressor of Ras 2 |
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| Gene, Accession # | Entrez: 283455, 288691, 333050; Uniprot: Q3UVC0, Q6VAB6 |
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| Catalog # | PA5-75293 |
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| Price | |
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| Order / More Info | KSR2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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