| 产品详情 |
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| Antigenic Specificity | Ku70 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:100-1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Ku70 Polyclonal Antibody. Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA end |
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| Immunogen | n/a |
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| Other Names | CTA-216E10.7, CTC75, CTCBF, G22P1, KU70, ML8, TLAA |
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| Gene, Accession # | Entrez: 2547; Uniprot: P12956 |
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| Catalog # | IHC-00723 |
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| Price | |
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| Order / More Info | Ku70 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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