| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Abraxas |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry: 1:100-1:500 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Abraxas Polyclonal Antibody. CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist. |
|---|
| Immunogen | n/a |
|---|
| Other Names | UNQ496/PRO1013, ABRA1, CCDC98, FLJ11520, FLJ12642, FLJ13614, BRCA1-A complex subunit Abraxas, abraxas protein, coiled-coil domain containing 98, coiled-coil domain-containing protein 98 |
|---|
| Gene, Accession # | Entrez: 84142; Uniprot: Q6UWZ7 |
|---|
| Catalog # | IHC-00630 |
|---|
| Price | |
|---|
| Order / More Info | Abraxas Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|