| 产品详情 |
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| Antigenic Specificity | Phospho-IKK alpha/beta (Ser176, Ser177) |
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| Clone | J.10.3 |
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| Host Species | Rabbit |
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| Reactive Species | bovine, human, mouse, nonhuman primate, rat |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-IKK alpha/beta (Ser176, Ser177) Monoclonal Antibody (J.10.3). NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine) |
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| Immunogen | n/a |
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| Other Names | Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, IKK1, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA, Transcription factor 16, TCF-16, CHUK, IKKA, TCF16 |
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| Gene, Accession # | Entrez: 1147, 12675, 16150, 281073, 281854, 309361, 3551, 84351; Uniprot: O14920, O15111, O88351, Q60680, Q95KV0, Q95KV1, Q9QY78 |
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| Catalog # | MA5-14857 |
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| Price | |
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| Order / More Info | Phospho-IKK alpha/beta (Ser176, Ser177) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 23180582 |
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