| 产品详情 |
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| Antigenic Specificity | Phospho-IKK alpha/beta (Ser180, Ser181) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-IKK alpha/beta (Ser180, Ser181) Polyclonal Antibody. The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK alpha and IKK beta serve as the catalytic subunits of the kinase and IKK gamma serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 |
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| Immunogen | n/a |
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| Other Names | I kappa-B kinase alpha, IkBKA, IKK-alpha, IKK-A, IkappaB kinase, EC 2.7.11.10, I-kappa-B kinase 1, IKK1, Conserved helix-loop-helix ubiquitous kinase, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA, CHUK, IKKA, TCF16, IKK-beta, IKK2, IKKB, NFKBIKB; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; inhibitor of nuclear factor kappa-B kinase subunit beta; nuclear factor NF-kappa-B inhibitor kinase beta |
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| Gene, Accession # | Entrez: 1147, 12675, 16150, 3551; Uniprot: O14920, O15111, O88351, Q60680 |
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| Catalog # | PA5-38255 |
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| Price | |
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| Order / More Info | Phospho-IKK alpha/beta (Ser180, Ser181) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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