| 产品详情 |
| Edit |   |
|---|
| Product Name | Rolipram |
|---|
| Description | Purity >98%. Type 4 cyclic nucleotide phosphodiesterases (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Rolipram is a cell-permeable selective PDE4 inhibitor. Since PDE4 is abundant in leukocytes, rolipram inhibits inflammation by suppressing leukocyte function, inhibiting C5a-stimulated LTC4 synthesis in eosinophils (IC50 = 200 nM), and lipopolysaccharide-induced TNF synthesis in monocytes (IC50 = 360 nM). Rolipram also enhances neuronal survival, has antipsychotic effects in mice, and suppresses bone loss in ovariectomized rats. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, SB 95952, ZK 62711 |
|---|
| Gene, Accession, CAS # | CAS: 61413-54-5 |
|---|
| Catalog # | LS-H9754 |
|---|
| Price | |
|---|
| Order / More Info | Rolipram from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|