| 产品详情 |
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| Product Name | DNA Base Excision Repair Pathway Inhibitor |
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| Description | Purity >98%. Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5' to the abasic site to produce a single strand break. DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM). Although not toxic to cells by itself at 200 µM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration. DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-nitro-1H-indole-2-carboxylic acid, 7-Nitroindole-2-Carboxylic Acid, CRT0044876, NSC 69877 |
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| Gene, Accession, CAS # | CAS: 6960-45-8 |
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| Catalog # | LS-H7548 |
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| Price | |
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| Order / More Info | DNA Base Excision Repair Pathway Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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